| 摘要 |
<p>The present application relates to a method of producing a diabetic rat comprising feeding rats for 1 to 2 weeks after weaning with a high fat diet. In a preferred embodiment, said rat is a ZDF rat. Said high fat diet is the diabetogenic diet which contains more than 6% fat, preferably more than 10% fat (saturated and/or unsaturated).
Preferably, weaning of the rats occurred after 5 to 6 weeks of age. In a preferred embodiment, said high fat diet comprises Kliba 2437. In a most preferred embodiment, rats are fed for 2 weeks after weaning with said high fat diet.
One important advantage of the rat produced by this method is that diabetes is reversible and that, thus, compound for interventive therapy can be identified, while with the known models, only compounds for preventive treatment can be identified since the induction of diabetes there is not reversible.</p> |
