发明名称 |
COMPOSITIONS AND METHODS FOR ACTIVATING STIMULATOR OF INTERFERON GENE -DEPENDENT SIGNALLING |
摘要 |
The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes), In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce human STING-dependent type I interferon production, wherein the cyclic purine dinuclotides present in the composition are 2'-fluoro substituted, bis-3',5'CDNs, and most preferably one or more 2',2"-diF-Rp,Rp, bis-3',5'CDNs. |
申请公布号 |
WO2016145102(A1) |
申请公布日期 |
2016.09.15 |
申请号 |
WO2016US21597 |
申请日期 |
2016.03.09 |
申请人 |
ADURO BIOTECH, INC. |
发明人 |
KATIBAH, George Edwin;KANNE, David;SUNG, Leonard;GAUTHIER, Kelsey;GLICKMAN, Laura Hix;LEONG, Justin;MCWHIRTER, Sarah, M.;DUBENSKY, Jr., Thomas, W. |
分类号 |
A61K39/12;A61K39/39;C07H21/02 |
主分类号 |
A61K39/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|