| 摘要 |
<p>Disclosed is a canine immunogenic composition comprising parvovirus virions that have a type VP-2 protein, said parvovirus virions comprising a nucleic acid, said nucleic acid comprising the nucleotide sequence selected from the group consisting of: SEQ ID NO: 2; a sequence that is at least 95% homologous to SEQ ID NO: 2 wherein nucleotides 16-18 are CTG to encode Leu at positions 431 of said VP-2 protein; SEQ ID NO:4; and a sequence that is at least 95% homologous to SEQ ID NO:4 wherein nucleotides 43-45 are GCA to encode Ala at position 440 of said VP-2 protein. Further disclosed is a diagnostic kit for detecting parvovirus in domestic dogs and puppies, wild canids, wolves, wild dogs, domestic cats and kittens, wild cats, minks, red pandas, foxes, lions, tigers, animals in zoos or protected areas, and animals in research facilities, comprising: molecules specific for detecting, in domestic dogs and puppies, wild canids, wolves, wild dogs, domestic cats and kittens, wild cats, minks, red pandas, foxes, lions, tigers, animals in zoos or protected areas, and animals in research facilities, a nucleic acid sequence selected from the group consisting of: a sequence that is at least 95% homologous to SEQ ID NO: 2 wherein nucleotides 16-18 are CTG to encode Leu at position 431 of a VP-2 protein; and a sequence that is at least 95% homologous to SEQ ID No:4 wherein nucleotides 43-45 are GCA to encode Ala at position 440 of a VP-2 protein.</p> |
