摘要 |
PROBLEM TO BE SOLVED: To provide a compound useful for treating cyclooxygenase-2 mediated diseases, to provide a process for synthesis of the compound, and to provide pharmaceutical compositions containing the compound. SOLUTION: The composition contains the Form V polymorph of Compound A of structural formula (A) which is nontoxity and selectively inhibits cyclooxygenase-2. The compound is obtained by heating the Form I, Form II, Form III and Form IV polymorph in isopropyl acetate at a temperature lower than about 75°C, cooling the resultant and isolating therefrom. COPYRIGHT: (C)2005,JPO&NCIPI
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