Chemical Compounds

摘要

Use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use as a Nuclear Factor-kB (NF-kB) inhibitor wherein: A has the following structure; Z is -COOH, -P(O)(OH)₂ or -SO₂OH; each R¹ is the same or different and is halogen, hydroxy, C_1-6 alkyl, C_2-6 alkenyl, C_2-6 alkynyl, C_1-6 alkoxy, C_1-6 alkylthio, thio, amino, mono(C_1-6 alkyl)amino, di(C_1-6 alkyl)amino, nitro, cyano or -CO₂R', wherein R' represents hydrogen or C_1-6 alkyl; n is 0, 1, 2 or 3; R² is hydrogen, C_1-6 alkyl, C_2-6 alkenyl or C_2-6 alkynyl; Y is a linking group; and X is C_1-6 alkyl, C_2-6 alkenyl, C_2-6 alkynyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, -M-aryl, -M-heteroaryl, -M-carbocyclyl or -M-heterocyclyl, wherein M is C_1-6 alkylene, C_2-6 alkenylene, C_2-6 alkynylene, -Q-Het-Q'- or -Q-Het- wherein Q and Q' are the same or different and are C_1-6 alkylene, C_2-6 alkenylene or C_2-6 alkynylene and Het is selected from -NR'-, -O-, -S-, -SO₂-, -SO-, -C(O)-O-, -OC(O), -CO-, -C(O)-NR'- or -NR'-C(O)- wherein R' is as defined above, provided that: when n is 0, Z is -COOH, R² is hydrogen and Y is -N-N-, X is other than 2-pyridyl.