A process for reducing the tendency of a drug substance to aggregate and/or agglomerate during storage. The process involves micronising the drug substance to give a mean particle size of less than about 10 µm, and exposing the micronised drug substance to a dry environment at an elevated temperature between 40° C and 120° C for at least six hours.
申请公布号
WO2009074662(A2)
申请公布日期
2009.06.18
申请号
WO2008EP67359
申请日期
2008.12.11
申请人
NOVARTIS AG;MUHRER, GERHARD;RASENACK, NORBERT;JUHNKE, MICHAEL