发明名称 |
Combination therapies comprising anti-ERBB3 agents |
摘要 |
Disclosed are methods and compositions for inhibiting the growth of a tumor (e.g., a malignant tumor) in a subject. In particular, combination therapies for treating a tumor in a subject by co-administering an agent selected from i) an effective amount of an anti-estrogen agent; ii) an effective amount of a receptor tyrosine kinase inhibitor; iii) an effective amount of a MEK/PI3 kinase/AKT inhibitor; iv) an effective amount of MM-151; v) an effective amount of an mTOR inhibitor; and/or vi) an effective amount of trastuzumab or TMD1, and/or combinations thereof; and an effective amount of a bispecific anti-ErbB2/anti-ErbB3 antibody. Also disclosed is a bispecific anti-ErbB2/anti-ErbB3 antibody for use in the therapy of a tumor in combination with an agent selected from i) an effective amount of an anti-estrogen agent; ii) an effective amount of a receptor tyrosine kinase inhibitor; iii) an effective amount of a MEK/PI3 kinase/AKT inhibitor; iv) an effective amount of MM-151; v) an effective amount of an mTOR inhibitor; and/or vi) an effective amount of trastuzumab or TMD1, and/or combinations thereof. |
申请公布号 |
US9345766(B2) |
申请公布日期 |
2016.05.24 |
申请号 |
US201314015776 |
申请日期 |
2013.08.30 |
申请人 |
Merrimack Pharmaceuticals, Inc. |
发明人 |
Zhang Bo;McDonagh Charlotte;Huhalov Alexandra |
分类号 |
A61K39/395;C07K16/46;A61K45/06;A61K31/565;A61K31/138;A61K31/4196;A61K31/517;A61K33/24;A61K31/7068;C07K16/32;A61K31/337;A61K31/436;A61K31/519;A61K31/567;C07K16/28;C07K16/40;A61K39/00 |
主分类号 |
A61K39/395 |
代理机构 |
Clark & Elbing LLP |
代理人 |
Clark & Elbing LLP |
主权项 |
1. A method of treating a subject with a malignant tumor, the method comprising co-administering to the subject an effective amount of trametinib and a bispecific anti-ErbB2/anti-ErbB3 antibody that inhibits heregulin activation of ErbB2 and ErbB3 and, optionally, an effective amount of trastuzumab or ado-trastuzumab emtansine, wherein the co-administration to the subject creates a substantially superadditive effect. |
地址 |
Cambridge MA US |