Moesin modulators and uses thereof

摘要

The present application provides compositions and methods useful for treating and diagnosing diseases and disorders associated with moesin activation.

主权项

1. A composition comprising a moesin inhibitor capable of inhibiting the activation of human moesin, wherein the moesin inhibitor consists of a truncated moesin fragment having ten contiguous amino acid residues of the last 34 amino acid residues of the C-terminal tail domain of human moesin as set forth in SEQ ID NO:1; and wherein the truncated moesin fragment comprises the phosphorylation site Threonine 558.