Anti-SSX-2 T cell receptors and related materials and methods of use

摘要

The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for synovial sarcoma X Breakpoint (SSX)-2. The invention further provides related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells. Further provided by the invention are antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are further provided by the invention.

主权项

1. An isolated or purified T cell receptor (TCR) comprising the amino acid sequences of SEQ ID NOs: 13-18, SEQ ID NO: 21 and SEQ ID NO: 22, wherein
the TCR has antigenic specificity for synovial sarcoma X Breakpoint (SSX)-2 (SEQ ID NO: 1) presented in the context of an HLA-A2 molecule, wherein the TCR also recognizes SSX-4 (SEQ ID NO: 4), and wherein the TCR is a human/mouse chimeric TCR.