| 发明名称 |
NON-IMMUNOGENIC SINGLE DOMAIN ANTIBODIES |
| 摘要 |
The invention provides modifications within human or humanized single domain antibody fragments (sdAbs) that prevent recognition by pre-existing antibodies, to isolated polypeptides that include these modifications, and to methods and uses thereof. |
| 申请公布号 |
US2016207981(A1) |
申请公布日期 |
2016.07.21 |
| 申请号 |
US201615003234 |
申请日期 |
2016.01.21 |
| 申请人 |
Inhibrx LP |
发明人 |
ECKELMAN BRENDAN P.;TIMMER JOHN C.;DEVERAUX QUINN |
| 分类号 |
C07K16/00 |
主分类号 |
C07K16/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A single domain antibody (sbAb) comprising at least one mutation that prevents recognition of the sbAb by an antibody that specifically recognizes single domain antibodies. |
| 地址 |
La Jolla CA US |
