| 发明名称 |
Fluorinated 2-arylbenzo heterocyclic compound with high affinity to A beta 946; plaques and containing chiral side chain substituent, and preparation method and usage thereof |
| 摘要 |
A fluorinated 2-arylbenzo heterocyclic compound with high affinity to Aβ plaques and containing a chiral side chain substituent, has a general formula (I) as follows:;wherein X is N; Y is S or O; Z is N or CH; R1 is a 5 or 6-substituent and is;;F is 19F or 18F; R2 is NHCH3 or N(CH3)2. The compound of the present invention has high affinity to Aβ plaques and can be used to make appropriate radioactive nuclide labeling probes for early diagnosis of AD. |
| 申请公布号 |
US2016207910(A1) |
申请公布日期 |
2016.07.21 |
| 申请号 |
US201414890922 |
申请日期 |
2014.11.07 |
| 申请人 |
BEIJING ZHIBO BIO-MEDICAL TECHNOLOGY CO., LTD |
发明人 |
Cui Mengchao;Lin Chunping;Liu Boli;Guo Yuzhi;Zhang Zhiyong |
| 分类号 |
C07D417/04;A61K51/04;C07D413/04;C07D277/66;C07D263/57 |
主分类号 |
C07D417/04 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A fluorinated 2-arylbenzo heterocyclic compound with high affinity to Aβ plaques and containing a chiral side chain substituent, wherein a general formula (I) thereof is as follows: wherein, X is N; Y is S or O; Z is N or CH; R1 is a 5 or 6-substituent and isF is 19F or 18F;
R2 is NHCH3 or N(CH3)2. |
| 地址 |
Beijing CN |
