| 主权项 |
1. A compound having formula I: or a pharmaceutically acceptable salt, and including deuterated forms thereof, wherein: Z1 is —C(R8)— or —N—; Z2 is —C(R7)— or —N—; Z3 is —C(R6)— or —N—; Z4 is —C(R5)— or —N—; Z5 is —O—, —S—, —S(O)—, —S(O)2—, —NRx— or —C(Rx)2—; R1, R1′, R3, and R3′ are each independently selected from D, Rx, C(H)2ORx, C(H)2OC(═O)Rx, C(═O)ORx, C(═O)N(H)Rx, C(═O)Rx, and OC(═O)Rx; and optionally R1 and R1′ taken together form oxo (═O); and optionally R3 and R3′ taken together form oxo (═O); each of R5, R6, R7 and R8, which can be the same or different, are independently selected from H, D, halo, Rx, —ORx, —SRx, —N(Rx)2, —N(Rx)C(═O)ORx, —C(═O)N(Rx)2, —C(═O)ORx, —C(═O)Rx, —OC(═O)Rx, —NO2, —CN, —N3, and —P(═O)(Rx)2; or R5 and R6, together with the carbon atoms to which they are respectively attached, form an unsubstituted or substituted cycloalkyl or heterocyclic ring, wherein the substituents are one to three substituents independently selected from halo, aryl, Rx, hydroxyl nitro, amino, alkoxy, alkylthio, —CO2H, and CN; or R6 and R7, together with the carbon atoms to which they are respectively attached, form an unsubstituted or substituted cycloalkyl or heterocyclic ring, wherein the substituents are one to three substituents independently selected from halo, aryl, Rx, hydroxyl, nitro, amino, alkoxy, alkylthio, —CO2H, and CN; R2 is -L1-L2-G; L1 is —C(O)—, —C(O)C(O)— or —(C1-C6)alkyl optionally substituted with 1-3 halo; —(C1-C3)alkyl optionally substituted with 1-3 groups independently selected from halo and D; —(C1-C3)alkoxy optionally substituted with 1-3 groups independently selected from halo and D; or a spiro-(C3-C6)cycloalkyl optionally substituted with 1-2 groups independently selected from halo, D, methyl, and halogenated methyl; L2 is —O—, oxycarbonylaryl or oxycarbonylheteroaryl, wherein each aryl or heteroaryl group of L2 is optionally substituted with one to three substituents independently selected from halo, D, —(C1-C6)alkyl, hydroxyl, nitro, amino, alkoxy, alkylthio, —CO2H, and CN; G is either absent or is one to three NO donors, provided that when G is absent, at least one of Z1, Z2, Z3 or Z4 is a nitrogen atom; R4 and R4′ are each independently selected from H, D and Rx; or are combined to form oxo; or R3 and R4 together with the carbon atoms to which they are respectively attached, form an unsubstituted or substituted cycloalkyl or heterocyclic ring, wherein the substituents are one to three substituents independently selected from halo, aryl, Rx, hydroxyl nitro, amino, alkoxy, alkylthio, —CO2H, and CN; each Rx is independently selected from H, D, alkyl, alkenyl, alkynyl, alkoxy, alkoxyalkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, cycloalkylalkyl, heterocyclylalkyl, arylalkyl, and heteroarylalkyl, wherein the alkyl, alkenyl or alkynyl portions of Rx can be optionally substituted with one to three substituents selected from halo, D, hydroxyl nitro, amino, —CO2H and —CN. |
