发明名称 |
DUAL ANTAGONISM OF ENDOTHELIN TYPE A AND BRADYKININ B1 RECEPTORS FOR TREATING PAIN AND PREVENTING CARTILAGE DEGRADATION |
摘要 |
The present invention relates to the field of anatomy, and more particularly to the control of pain and to the prevention and treatment of osteoarthritic cartilage degradation. Described herein are methods for treating pain which comprise administering to a subject in need a combination of (i) an antagonist of the endothelin type A receptor (ETA) and (ii) an antagonist of the bradykinin B1 receptor (BKB1). Also described are methods for preventing osteoarthritic cartilage degradation and pharmaceutical compositions for treating pain, for preventing osteoarthritic cartilage degradation, and/or for preventing osteoarthritic joint inflammation, in subjects.
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申请公布号 |
CA2766684(A1) |
申请公布日期 |
2012.08.04 |
申请号 |
CA20122766684 |
申请日期 |
2012.02.03 |
申请人 |
MOLDOVAN, FLORINA;KAUFMAN, GABRIEL;SIROIS, PIERRE |
发明人 |
MOLDOVAN, FLORINA;KAUFMAN, GABRIEL;SIROIS, PIERRE |
分类号 |
A61K38/12;A61K38/08;A61P25/02;A61P29/00 |
主分类号 |
A61K38/12 |
代理机构 |
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