发明名称 |
Immunoadjuvant flagellin-based compounds and use thereof |
摘要 |
The present invention relates to novel peptide compounds derived from flagellin originating from Salmonella enterica that exhibit an in vivo immune adjuvant activity. |
申请公布号 |
US9527891(B2) |
申请公布日期 |
2016.12.27 |
申请号 |
US200913000167 |
申请日期 |
2009.06.23 |
申请人 |
INSERM (Institut National de la Santé et de la Recherche Médicale);INSTITUT PASTEUR DE LILLE |
发明人 |
Sirard Jean-Claude |
分类号 |
C07K14/255;A61K39/39;A61K39/00 |
主分类号 |
C07K14/255 |
代理机构 |
Whitham, Curtis & Cook, P.C. |
代理人 |
Whitham, Curtis & Cook, P.C. |
主权项 |
1. An immunoadjuvant compound comprising:
a) a N-terminal peptide having at least 95% amino acid identity with the amino acid sequence starting from the amino acid residue located at position 1 of SEQ ID No 1 and ending at an amino acid residue selected from the group consisting of any one of the amino acid residues located at positions 99 to 173 of SEQ ID No 1; and b) a C-terminal peptide, wherein the said C-terminal peptide is selected from the group consisting of the amino acid sequences 401-494 and 406-494 of SEQ ID NO1, wherein: the said N-terminal peptide is linked to the said C-terminal peptide one to the other, through a spacer chain, the spacer chain consisting of 1 to 20 amino acids linked by peptide bonds, wherein the amino acids are selected from the 20 naturally-occurring amino acids and wherein (i) the said N-terminal and C-terminal peptides consist of the amino acid sequences 1-137 and 406-494 of SEQ ID No 1, respectively; or (ii) said N-terminal peptide and the said C-terminal peptide are indirectly linked, one to the other, through an intermediate spacer chain consisting of NH2-Gly-Ala-Ala-Gly-COOH peptide sequence (SEQ ID NO 31). |
地址 |
Paris FR |