| 发明名称 | Purification of taxanes | ||
| 摘要 | Disclosed is a method of crystallizing docetaxel comprising combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is methylene chloride and adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water. | ||
| 申请公布号 | US9527825(B2) | 申请公布日期 | 2016.12.27 |
| 申请号 | US201615053793 | 申请日期 | 2016.02.25 |
| 申请人 | Phyton Holdings, LLC | 发明人 | Bucher Brian A.;Desimone, III Edward M.;Franke Roland R.;Gallagher Rex T.;Hand Barry J.;Howe Christopher D.;Johnson James H.;Juchum John S.;Plante Marc A.;Sambandam T. G.;Yang Dong S. |
| 分类号 | C07D305/14;C07D407/12 | 主分类号 | C07D305/14 |
| 代理机构 | Norton Rose Fulbright US LLP | 代理人 | Norton Rose Fulbright US LLP |
| 主权项 | 1. A method of crystallizing docetaxel comprising: (a) combining docetaxel and at least one solubilizing solvent to obtain a solution, wherein the solubilizing solvent is methylene chloride; and (b) adding an anti-solvent to the solution to obtain a crystalline docetaxel, wherein the anti-solvent is water. | ||
| 地址 | San Antonio TX US | ||