PRODUCTION METHOD OF CYST EXPRESSED TRANSGENIC ANIMAL USING PKD2 GENE

摘要

Disclosed herein is a method for producing a cyst-expressed transgenic animal using a PKD2 gene. The production method comprises preparing a PKD2 protein expression vector, inserting the expression vector into the nucleus of a fertilized egg to produce a PKD2 expression vector-containing fertilized egg, and transplanting the produced fertilized egg into the uterus of a surrogate mother. According to the invention disclosed herein, there is provided a method for producing transgenic animals, in which cysts are expressed only by the over express ion of the PKD2 gene. Also, transgenic mice are provided which can be effectively used in the investigation of cyst expression mechanisms and cyst control systems.