发明名称 |
Novel efficient production process for capsular polysaccharides of pathogenic Gram-positive bacteria by heterologous expression and secretion of complex polysaccharides in non-pathogenic, non-invasive Gram-positive bacteria |
摘要 |
The current invention provides methods and means for heterologous expression, production and/or secretion of complex capsular polysaccharides in non-pathogenic, non-invasive Gram-positive bacteria. The invention in particular provides non-pathogenic, non-invasive Gram-positive bacteria capable of expression and/or secretion of heterologous, complex polysaccharides from a pathogenic bacterial species. Such bacteria and polysaccharides produced therein may be applied according to the invention to provide compositions for vaccination for the treatment and prevention of infectious bacterial diseases. |
申请公布号 |
ZA200705190(B) |
申请公布日期 |
2008.09.25 |
申请号 |
ZA20070005190 |
申请日期 |
2007.06.27 |
申请人 |
STICHTING TOP INSTITUTE FOOD AND NUTRITION |
发明人 |
NIEROP GROOT, MASJA NATHALIE;KLEEREBEZEM, MICHIEL;DE VOS, WILLEM MEINDERT |
分类号 |
A61K;C07K;C12N |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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