Target vector with activable imaging function

摘要

The invention concerns the field of molecular probe architecture for in vivo imaging. More particularly, the invention concerns molecular constructs providing an imaging function activable in intracellular environment. The inventive fluorescence probes enable in particular images of certain targeted tissues to be formed, while maintaining a low background noise level and, preferably, while obtaining at the targeted tissue, an imaging signal increasing in time.

主权项

1. A targeted biological vector comprising:
a Regioselectively Addressable Functionalized Template (RAFT) cyclodecapeptide vector core bound to: (i) at least one targeting molecule which is a peptide that comprises a RGD motif, and (ii) at least one activatable imaging function provided by a first fluorophore linked to a fluorescence quencher by an arm that is cleavable in an intracellular medium; wherein said arm comprises two adjacent cysteine residues bound by a disulfide bridge; and wherein said fluorophore is Cyanine 5 (Cy5), and said fluorescent quencher is QSY21.