发明名称 |
PYRIDOPYRIMIDINE OR PYRIMIDOPYRIMIDINE COMPOUND, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF |
摘要 |
The present invention belongs to the field of pharmaceutical Chemistry. In particular, the present invention relates to a pyridopyrimidine or pyrimidopyrimidine compound as represented by general formula (I), or an isomer thereof or a pharmaceutical acceptable salt, ester, prodrug or solvate thereof, a preparation method, a pharmaceutical composition and uses thereof in preparing a mTOR inhibitor. As a mTOR inhibitor, the compound or the pharmaceutical composition thereof can be used for treating a disease or condition due to PI3K-AKT-mTOR signalling pathway malfunction. |
申请公布号 |
EP2966079(A4) |
申请公布日期 |
2016.11.09 |
申请号 |
EP20140760712 |
申请日期 |
2014.02.28 |
申请人 |
SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES;FUDAN UNIVERSITY |
发明人 |
SHEN, JINGKANG;YU, KE;MENG, TAO;MA, LANPING;ZASK, ARIE;MENG, LANFANG;WANG, XIN;CHEN, YIYI |
分类号 |
C07D519/00;A61K31/5377;A61K31/5386;A61P35/00;A61P35/02;C07D471/04;C07D487/04 |
主分类号 |
C07D519/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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