发明名称 Nanometer-sized prodrugs of NSAIDs
摘要 The present invention describes nanoprodrugs of non-steroidal anti-inflammatory drug (NSAIDs) and nanoprodrugs of α-lipoic acid-containing and NSAIDs. These nanoprodrugs have antioxidant properties and stimuli-responsiveness, which can be used to treat various disease conditions.
申请公布号 US9504753(B2) 申请公布日期 2016.11.29
申请号 US201314069001 申请日期 2013.10.31
申请人 Cedars-Sinai Medical Center 发明人 Yu John S.;Lee Bong Seop
分类号 A61K47/48;A61K9/14;C07D339/04 主分类号 A61K47/48
代理机构 Nixon Peabody LLP 代理人 Nixon Peabody LLP ;Huber Linda B.
主权项 1. A molecule having formula I: wherein the A is a moiety that is formed by esterification of at least two free esterifiable hydroxyl groups on a polyol selected from the group consisting of wherein n on the polyol is an integer between 3 and 16,and n of Formula I is an integer of at least two, wherein the NSAID is selected from the group consisting of aspirin, ibuprofen, ketoprofen, fenoprofen, fenbufen, indomethacin, diclofenac, ketorolac, tolmetin, flufenamic acid, mefenamic acid, tolfenamic acid, meclofenamic acid, niflumic acid, sulindac, sulindac sulfide and combinations thereof.
地址 Los Angeles CA US