Retinaldehyde mimetics and inhibitors of retinaldehyde dehydrogenase I in the treatment of disorders

摘要

The technology described herein is directed to methods of treating, e.g. obesity by administering retinaldehyde increasing agents.

主权项

1. A method of inducing a brown adipose tissue (BAT)-like phenotype in a white adipose tissue (WAT) of a subject; the method comprising administering a therapeutically effective amount of a retinaldehyde increasing agent to the subjectwherein the retinaldehyde increasing agent is an inhibitory nucleic acid comprising the sequence of SEQ ID NO:1.