| 发明名称 |
COMPOSITIONS AND METHODS FOR SENSITIZING A NEOPLASTIC CELL TO RADIATION |
| 摘要 |
The invention provides for the use of radiation sensitizing agents in combination with radiation for the treatment of neoplasia, methods for the identification of genotype-specific radiation sensitizing agents, and methods of identifying patients who could benefit from therapy with a genotype-specific radiation sensitizing agent. |
| 申请公布号 |
US2016367561(A1) |
申请公布日期 |
2016.12.22 |
| 申请号 |
US201615250402 |
申请日期 |
2016.08.29 |
| 申请人 |
THE BROAD INSTITUTE, INC. ;THE BRIGHAM AND WOMEN'S HOSPITAL, INC. ;DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
ABAZEED MOHAMED;MEYERSON MATTHEW;ADAMS DREW |
| 分类号 |
A61K31/5377;C12Q1/68;G01N33/50;A61K41/00 |
主分类号 |
A61K31/5377 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method of sensitizing a neoplastic cell to radiation, the method comprising contacting the cell with a P13 kinase inhibitor and exposing the cell to radiation, thereby sensitizing the cell to radiation, wherein the cell comprises a TP53 or NFE2L2 mutation. |
| 地址 |
Cambridge MA US |
