METHODS AND COMPOSITIONS FOR ENHANCING VASCULAR ACCESS

摘要

Disclosed is an implantable material comprising a biocompatible matrix and
cells which, when provided to a vascular access structure, can promote
functionality generally. For example, implantable material of the present
invention can enhance maturation of an arteriovenous native fistula as well as
prolong the fistula in a mature, functional state suitable for dialysis.
Additionally, the present invention can promote formation of a functional
arteriovenous graft suitable for dialysis as well as promote formation of a
functional peripheral bypass graft. Implantable material can be configured as
a flexible planar form or a flowable composition with shape~retaining
properties suitable for implantation at, adjacent or in the vicinity of an
anastomoses or arteriovenous graft. According to the methods disclosed herein,
the implantable material is provided to an exterior surface of a blood vessel.
Certain embodiments of the flexible planar form define a slot. The materials
and methods of the present invention comprise cells, preferably endothelial
cells or cells having an endothelial-like phenotype.