INVOLVEMENT OF LIPID KINASE, AND SIGNAL TRANSDUCTION PATHWAY COMPRISING SAID LIPID KINASE, IN RESISTANCE TO HER2-TARGETING THERAPY

摘要

The invention is related to a method for determining whether an individual suffering from cancer is at risk of exhibiting or acquiring a reduced response towards HER2-targeting therapy. In one aspect, the invention utilizes the activity of a signal transduction pathway modulated by a lipid kinase for determining said risk.