| 摘要 |
<p>PROBLEM TO BE SOLVED: To provide a new novel sulfone derivative that is useful as a synthetic intermediate for retinol useful in the fields of medicines and feed additives. SOLUTION: This compound is represented by formula I [Ar is a (substituted) aryl; X is a halogen; R is a protecting group for a hydroxyl group] or by formula II, typically a compound of formula III or formula IV (Ts is p-tolylsulfonyl). The compound of formula I or formula II is prepared by reaction of a sulfone compound of formula V with a halide usually in an amount of 0.3-1.5 mole per mole of the sulfone compound (for example, a halide of the group 4 transition metal such as titanium tetrachloride or sulfur or phosphorus halide in a suitable organic solvent in a temperature range from -78 deg.C to the boiling point of the solvent, preferably in the range of from -10 to +50 deg.C, usually for 1 to 24 hours.</p> |
