PROCESS FOR PRODUCING (3R,5S)-(E)-7-[2-CYCLOPROPYL-4-(4-FLUOROPHENYL)-QUINOLIN-3-YL]-3,5-DIHYDROXYHEPT-6-ENIC ACID ESTERS
摘要
A process for producing a compound represented by the following general formula (IV): (IV) wherein R represents hydrogen, alkyl or aryl; characteriz ed by reducing a compound selected from the group consisting of compounds represented by the following general formula (I): (I) wherein R is as define d above; compounds represented by the following general formula (II): (II) wherein R is as defined above; and compounds represented by the following general formula (III): (III) wherein R is as defined above; by treating optionally processed cells of a microorganism capable of stereoselectively reducing a keto group.
申请公布号
CA2437312(A1)
申请公布日期
2002.08.15
申请号
CA20022437312
申请日期
2002.02.01
申请人
MITSUBISHI CHEMICAL CORPORATION;NISSAN CHEMICAL INDUSTRIES, LTD.