CYCLIC ETHER AMIDE COMPOUND

摘要

PROBLEM TO BE SOLVED: To provide a new cyclic ether amide lipid constructing molecular aggregates by self-organization, and a lipid membrane forming a moderate intramolecular hydrogen bond. SOLUTION: This new cyclic ether amide lipid of 2 glycerol derivatives and 2 long chain alkyl compounds, having a diether bond backbone and an amide bond backbone simultaneously is obtained by synthesizing a diether lipid of a glycerol derivative building-in asymmetric groups and the long chain alkyl compound and then passing through a new intermediate material obtained by introducing an azide group having high reactivity. The obtained cyclic ether amide lipid is provided by forming the molecular aggregates by the self-organization, having a property close to that of a cyclic amide lipid and forming a lipid membrane having a somewhat weakened intramolecular hydrogen bond. COPYRIGHT: (C)2008,JPO&INPIT