Theranostic Nanoprobes for Overcoming Cancer Multidrug Resistance and Methods

摘要

Theranostic nanoprobes are provided for overcoming cancer multidrug resistance, and methods for treating biological tissue, including cancerous tissue. The theranostic nanoprobes may include gold nanoparticles functionalized with DNA-hairpin. The DNA-hairpin may be configured to hybridize to a complementary target, which may silence or lessen the multidrug resistance of cancer cells. The theranostic nanoprobes may be configured to release a chemotherapeutic agent upon hybridization of the DNA-hairpin to a target molecule.

主权项

1. A theranostic nanoprobe comprising:
a gold nanoparticle functionalized with
at least one DNA-hairpin labeled with a fluorophore, andat least one anchor labeled with a quencher; and a chemotherapeutic agent intercalated in the at least one DNA-hairpin; wherein the at least one DNA-hairpin is configured to hybridize to a complementary target in a cancer cell.