NOVEL ANTI-VIRAL THERAPEUTIC

摘要

Anti-viral therapeutics for use in viral targets having VPg unlinkase activity, including the broad class of picornaviruses, and therapeutic methods directed at suppression of such activity are provided. Such anti-viral therapies for use against human rhinovirus, for example, are particularly desirable as they would lessen both the severity and duration of upper respiratory distress in both normal and asthmatic individuals. Assays and purification protocols for detecting and purifying VPg unlinkase are also provided.

主权项

1. A method of treatment or inhibiting picornavirus replication, said method comprising:
administering a therapeutically effective amount of an inhibitor compound to a human host infected with a picornavirus, said step of administering comprising one of intranasal, oral or intravenous administration of the inhibitor compound to the human host; and wherein the inhibitor compound inhibits the release of picornavirus viral protein genome-linked (VPg) by tyrosyl-DNA phosphodiesterase 2 (TDP2).