| 发明名称 |
MODULATORS OF GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE PROTEINS |
| 摘要 |
The present invention relates to glycerophosphodiester phosphodiesterase (GDE) proteins. More specifically, the present invention relates to targeting GDE proteins to modulate its glycosylphosphatidylinositol (GPI)-cleaving activity. In a specific embodiment, the present invention provides a GDE modulator that modulates the surface GPI anchor cleavage activity of GDE. |
| 申请公布号 |
US2016319324(A1) |
申请公布日期 |
2016.11.03 |
| 申请号 |
US201415107481 |
申请日期 |
2014.12.23 |
| 申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
Sockanathan Shanthini;Park Sungjin |
| 分类号 |
C12Q1/44;A61K31/714;A61K31/4402;A61K31/165;A61K31/192;A61K31/7048;A61K31/198 |
主分类号 |
C12Q1/44 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of screening for antagonists of a glycerophosphodiester phosphodiesterase (GDE) protein comprising the steps of:
a. contacting a test agent with a cell that expresses the GDE protein; and b. measuring the level of cleavage of glycosylphosphatidylinositol (GPI) anchors in the cell, wherein a test agent that decreases the measure cleavage level as compared to cleavage activity in a cell not contacted with the test agent identifies the test agent as an antagonist of GDE protein. |
| 地址 |
Baltimore MD US |
