发明名称 |
Use of miR-494 to Modulate TRAIL-induced Apoptosis through BIM Down-regulation |
摘要 |
Methods and compositions for inhibiting tumorigenicity both in vitro and in vivo in a subject in need thereof, comprising administering an effective amount of an anti-miR-494 nucleic acid construct sufficient to target one or more tumor suppressor genes (TSGs) are described. Activation of the ERK1/2 pathway is a major determinant of diverse cellular processes and cancer development and is responsible for the transcription of several important miRNAs. Described herein is a link between the ERK1/2 pathway and BIM expression through miR-494. This ERK1/2 pathway regulates apoptosis and cell proliferation through miR-494 and mechanisms responsible for TRAIL resistance. Materials and methods related to the study and treatment of cancer are described. |
申请公布号 |
US2016319285(A1) |
申请公布日期 |
2016.11.03 |
申请号 |
US201615213551 |
申请日期 |
2016.07.19 |
申请人 |
Ohio State Innovation Foundation |
发明人 |
Croce Carlo M.;Romano Giulia |
分类号 |
C12N15/113;G01N33/574;G01N33/68;C12Q1/68 |
主分类号 |
C12N15/113 |
代理机构 |
|
代理人 |
|
主权项 |
1. A method of affecting a cell by inhibiting proliferation of the cell and/or inducing apoptosis of the cell, the method comprising introducing an effective amount of a miR-specific inhibitor of at least miR-494 into a cell in need thereof. |
地址 |
Columbus OH US |