MELLEOLIDE-BIOSYNTHESIS GENE CLUSTER AND ITS APPLICATIONS

摘要

The present invention relates to the production of hydroxylated protoilludenes and/or sesquiterpenoid protoilludene-type aryl esters using newly identified genes that can be employed. The present invention accordingly relates to a host microorganism that has been transformed with the newly identified nucleotide sequences and to methods employing the transformed microorganism.

主权项

1. An isolated polynucleotide encoding a polypeptide with cytochrome-P450 monooxygenase activity, comprising or consisting of:
a) one of SEQ ID NOs: 5 to 8; b) a nucleic acid sequence complementary to one of SEQ ID NOs: 5 to 8; c) a nucleic acid sequence which hybridize under stringent conditions to the nucleic acid sequences defined in a) and b) or their complementary strands.