发明名称 |
UNIVERSAL DONOR STEM CELLS AND RELATED METHODS |
摘要 |
Disclosed herein are universal donor stem cells and related methods of their use and production. The universal donor stem cells disclosed herein are useful for overcoming the immune rejection in cell-based transplantation therapies. In certain embodiments, the universal donor stem cells disclosed herein do not express one or more MHC-I and MHC-II human leukocyte antigens. Similarly, in certain embodiments, the universal donor stem cells disclosed herein do not express one or more human leukocyte antigens (e.g., HLA-A, HLA-B and/or HLA-C) corresponding to MHC-I and MHC-II human leukocyte antigens, thereby rendering such cells hypoimmunogenic. |
申请公布号 |
WO2016183041(A2) |
申请公布日期 |
2016.11.17 |
申请号 |
WO2016US31551 |
申请日期 |
2016.05.09 |
申请人 |
PRESIDENT AND FELLOWS OF HARVARD COLLEGE |
发明人 |
MEISSNER, Torsten, B.;FERREIRA, Leonardo, M.r.;STROMINGER, Jack, L.;COWAN, Chad, A. |
分类号 |
C12N15/85;C12N5/0735 |
主分类号 |
C12N15/85 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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