发明名称 |
METHOD OF PURIFYING POLYPEPTIDES |
摘要 |
The present invention relates to improved processes for purifying polypeptides of interest by increasing the amount of a polypeptide of interest bound to an ion-exchange matrix relative to the amount of one or more impurities bound to the ion-exchange matrix. This effect is achieved by adding a chemical compound in the process which by also binding to the ion-exchange matrix due to a change that is opposite to the change of the ion-exchange matrix, reduces the binding of impurities more than the binding of the polypeptide of interest. |
申请公布号 |
KR20120108989(A) |
申请公布日期 |
2012.10.05 |
申请号 |
KR20127018780 |
申请日期 |
2010.12.15 |
申请人 |
CSL LTD. |
发明人 |
CHARLTON ADAM;NAPOLI MARK;SMRDELJ PAUL;STOWERS ANTHONY;PIRZAS VICKY;SCHROEDER MAGNUS;WALKER IAN |
分类号 |
C07K1/18;C07K14/435;C12N9/64 |
主分类号 |
C07K1/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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