发明名称 |
NITRIC OXIDE RELEASING PRODRUGS OF DIARYL-2-(5H)-FURANONES AS CYCLOOXYGENASE-2 INHIBITORS |
摘要 |
The invention encompasses novel compounds of Formula I, which are nitric oxi de- releasing prodrugs of diaryl-2-(5H) furanones useful in the treatment of cyclooxygenase-2 mediated diseases. Formula (I). The invention also encompasses certain pharmaceutical compositions and methods for treating cyclooxygenease-2 mediated diseases comprising the use of compounds of Formu la I. The above compounds may be used as a combination therapy with low-dose aspirin to treat chronic cyclooxygenase-2 mediated diseases or conditions while also reducing the risk of thrombotic cardiovascular events.
|
申请公布号 |
CA2554333(A1) |
申请公布日期 |
2005.08.04 |
申请号 |
CA20052554333 |
申请日期 |
2005.01.25 |
申请人 |
MERCK FROSST COMPANY |
发明人 |
WANG, ZHAOYIN;LI, LIANHAI;BEAULIEU, CHRISTIAN;STURINO, CLAUDIO F.;BERTHELETTE, CARL |
分类号 |
C07C217/46;A61K31/04;A61K45/06;A61P9/00;A61P29/00;C07C317/46 |
主分类号 |
C07C217/46 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|