| 摘要 |
PROBLEM TO BE SOLVED: To provide a pharmacological composition containing a compound having excellent GlyT2 inhibiting action as an active component. SOLUTION: The pharmacological composition contains a norvaline derivative expressed by formula (I) or its pharmacologically allowable salt as an active component. In the formula, X is -CH<SB>2</SB>-, -O-, -S- or a single bond; Ar is a (substituted)aryl or a (substituted)lower cycloalkyl; n is an integer of 0-2; R<SP>1</SP>, R<SP>2</SP>, R<SP>3</SP>and R<SP>4</SP>are (i) each independently hydrogen atom or lower alkyl, (ii) R<SP>1</SP>and R<SP>2</SP>together form lower alkylene or (iii) R is -N(R<SP>5</SP>)(R<SP>6</SP>) or -OR<SP>7</SP>, R<SP>5</SP>or R<SP>6</SP>; R<SP>5</SP>and R<SP>6</SP>are (i) each independently a lower alkyl which may be substituted with hydroxyl group, or hydrogen atom; (ii) R<SP>5</SP>and R<SP>6</SP>together with adjacent nitrogen atom form a nitrogen-containing aliphatic 5 to 6-membered heterocyclic group which may have substituents; and R<SP>7</SP>is a lower alkyl group. COPYRIGHT: (C)2008,JPO&INPIT
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