发明名称 |
MATERIALS AND METHODS FOR REDUCING INFLAMMATION BY INHIBITION OF THE ATRIAL NATRIURETIC PEPTIDE RECEPTOR |
摘要 |
This invention pertains to inhibitors of atrial natriuretic peptide receptor A (NPRA) function, such as small interfering RNA (siRNA), useful for reducing the inflammation associated with many human diseases, such as asthma, respiratory syncytial virus (RSV) infection, and cancers (such as melanoma, lung cancer, and/or ovarian cancer) by interfering with NPRA gene expression or otherwise reducing NPRA function within a subject; and methods for treating a subject suffering from, or at risk of developing, an inflammatory disease, respiratory allergy (such as allergic rhinitis and asthma), viral infection, and/or cancer by administering such NPRA inhibitors to the subject. |
申请公布号 |
WO2007127487(A3) |
申请公布日期 |
2008.04.24 |
申请号 |
WO2007US10572 |
申请日期 |
2007.04.30 |
申请人 |
UNIVERSITY OF SOUTH FLORIDA;MOHAPATRA, SHYAM, S.;XU, WEIDONG;KONG, XIAOYUAN;WANG, XIAOQIN |
发明人 |
MOHAPATRA, SHYAM, S.;XU, WEIDONG;KONG, XIAOYUAN;WANG, XIAOQIN |
分类号 |
A01N43/04;A61K31/70 |
主分类号 |
A01N43/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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