NOVEL PROCESS FOR DEVITALIZED/ACELLULAR TISSUE FOR TRANSPLANTATION
摘要
<p>A method for processing tissue to produce a devitalized acellular matrix for transplantation comprises soaking the tissue in a first processing solution having a pH below 7 to reduce protease activity, periodically infusing ozone into the first processing solution to devitalize the tissue and reduce bioburden, and soaking the tissue in a second processing solution to remove cellular debris. The present invention also includes a system for processing the tissue. The devitalized acellular matrix acts as a scaffold for cellular ingrowth when transplanted into a recipient to form new tissue.</p>
申请公布号
WO2008048663(A2)
申请公布日期
2008.04.24
申请号
WO2007US22225
申请日期
2007.10.18
申请人
BACTERIN INTERNATIONAL, INC.;SHELBY, NANCY JANE;FITZPATRICK, KRISTIN LEIGH;HOLMES, DARREL LEE
发明人
SHELBY, NANCY JANE;FITZPATRICK, KRISTIN LEIGH;HOLMES, DARREL LEE