RNA GUIDED ERADICATION OF HERPES SIMPLEX TYPE I AND OTHER RELATED HERPESVIRUSES

摘要

The present invention relates to compositions and methods for the inhibition of the infectivity of a herpesvirus.The compositions and methods provide a CRISPR-associated (Cas) peptide and a guide nucleic acid, which induce the mutation of herpesvirus genome, thereby inhibiting the infectivity of the herpesvirus. Further disclosed are Cas peptides including Cas9 or a variant thereof comprising one or more point mutations relative to wildtype Streptococcus pyogenes Cas9 (spCas9), and Cpfl or a variant thereof.