INTERVERTEBRAL DISC REPAIR, METHODS AND DEVICES THEREFOR

摘要

The present application discloses compositions, methods and devices for treatment of a degenerative intervertebral disc. A composition can comprise chondrocytes expressing type II collagen. These chondrocytes can be obtained from human cadavers up to about two weeks following death, and can be grown in vitro. The compositions can further comprise one or more biocompatible molecules. Treatment of a degenerative disc can comprise injecting or implanting a composition comprising the chondrocytes into a degenerative disc through an aperture or incision. If the aperture or incision is closed with a suture or a glue after introduction of the chondrocytes, the closure can withstand over 400 N of compression force.

主权项

1. A method of implanting viable chondrocytes in a degenerative intervertebral disc in a subject, the method comprising:
a) injecting through an opening in the annulus of the degenerative intervertebral disc, into the nucleus pulposus of the disc, a composition comprising: (i) a suspension of a population of viable articular cartilage chondrocytes; (ii) thrombin; and (iii) fibrinogen; b) forming a closure of the opening following injection of the cell suspension composition.