THERAPEUTIC COMPOUNDS AND USES THEREOF

摘要

Described herein are compounds of Formula (I) or Formula (VI), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of Formula (I) or Formula (VI) and pharmaceutical compositions thereof that are mucus penetrating. Methods of using the compounds or pharmaceutical compositions thereof for treating diseases are also provided.;

主权项

1. A pharmaceutical composition suitable for delivery to the eye, comprising a compound of Formula (I) and a pharmaceutically acceptable carrier: or a pharmaceutically acceptable salt thereof, wherein:
R1 is H or C1-6 alkyl;R2 is heterocyclyl;X is a bond, —O—, or —C(═O)—;each instance of R3 is H, F, Cl, Br, I, CN, or OH;Y is N;Z is optionally substituted aliphatic, optionally substituted heterocyclylalkyl, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted quinolyl;m is independently 0, 1, 2, 3, or 4; andn is independently 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.