| 发明名称 |
MICRO-PARTICULATED NANOCAPSULES CONTAINING LOPINAVIR WITH ENHANCED ORAL BIOAVAILABILITY AND EFFICACY |
| 摘要 |
The present disclosure provides controlled-release delivery systems for oral delivery of active agents, e.g. lopinavir, comprising micro-particulated with enhanced oral bioavailability and efficacy, which may be used for treating HIV. |
| 申请公布号 |
US2016235749(A1) |
申请公布日期 |
2016.08.18 |
| 申请号 |
US201615041610 |
申请日期 |
2016.02.11 |
| 申请人 |
Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. |
发明人 |
BENITA Simon;NASSAR Taher |
| 分类号 |
A61K31/513;A61K9/16;A61K9/51 |
主分类号 |
A61K31/513 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A controlled-release delivery system for oral delivery of lopinavir, the delivery system comprising at least microparticle formed of a hydrophilic polymeric matrix, and embedding at least one nanocapsule, the at least one nanocapsule comprises a core comprising lopinavir solubilized in at least one oil, and a shell comprising a hydrophobic polymer, the weight ratio of the lopinavir to the hydrophobic polymer being at least 1:1.5. |
| 地址 |
Jerusalem IL |
