| 发明名称 |
BETA-2 MICROGLOBULIN-DEFICIENT CELLS |
| 摘要 |
The invention provides isolated primate cells preferably human cells that comprise a genetically engineered disruption in a beta-2 microglobulin (B2M) gene, which results in deficiency in MHC class I expression and function. Also provided are the method of using the cells for transplantation and treating a disease condition. |
| 申请公布号 |
WO2012145384(A1) |
申请公布日期 |
2012.10.26 |
| 申请号 |
WO2012US34051 |
申请日期 |
2012.04.18 |
| 申请人 |
UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION;RUSSELL, DAVID, W. |
发明人 |
RUSSELL, DAVID, W. |
| 分类号 |
C07K14/705;A61K38/17;C12N15/85 |
主分类号 |
C07K14/705 |
| 代理机构 |
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