| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide humanized anti-CD70 binding agents and uses thereof. <P>SOLUTION: The invention provides CD70 antibodies and related CD70 binding agents and methods relating to the use of such binding agents for the prophylaxis or treatment of CD70-expressing cancers and immunological disorders where CD70-expressing cells are present. The CD70 binding agent, alone or in combination with a therapeutic agent, exerts a cytotoxic, cytostatic and/or immunomodulatory effect on CD70-expressing cells. In an aspect, CD70 binding agents are provided. The CD70 binding agent can be, for example, an antibody. In some embodiments, the binding agent includes at least one effector domain mediating at least an ADCC, ADCP or CDC response in the subject. <P>COPYRIGHT: (C)2013,JPO&INPIT |
