STRUCTURE AND FUNCTION OF THE SALICYLIC ACID BINDING SITES ON HUMAN HMGB1 AND METHODS OF USE THEREOF FOR THE RATIONAL DESIGN OF BOTH SALICYLIC ACID DERIVATIVES AND OTHER AGENTS THAT ALTER ANIMAL AND PLANT HMGBS ACTIVITIES

摘要

Compositions and methods for identifying agents which 1) mimic salicylic acid binding to human, animal and plant high mobility group box proteins or 2) alter activities of these HMGBs by binding in or around their salicylic acid-binding sites and agents so identified are disclosed.