METHODS FOR GENERATING RADIOIMMUNOCONJUGATES

摘要

PROBLEM TO BE SOLVED: To provide methods for generating an actinium 225 (Ac-225) radioconjugate.SOLUTION: A method for producing an actinium-225 (Ac-225) radioconjugate comprises: (a) conjugating a chelating agent to a biological molecule in a conjugation reaction mixture to generate a conjugated biological molecule, (b) purifying the reaction mixture so as to remove unconjugated chelating agents, and (c) chelating one or more Ac-225 radionuclides with the conjugated biological molecule in a chelation reaction mixture.SELECTED DRAWING: None