发明名称 Macrocyclic tetrazolyl hepatitis C serine protease inhibitors
摘要 The present invention relates to compounds of Formula I, II, III or IV, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising a compound of the present invention.
申请公布号 US8304385(B2) 申请公布日期 2012.11.06
申请号 US20080270963 申请日期 2008.11.14
申请人 SUN YING;LIU DONG;OR YAT SUN;WANG ZHE;ENANTA PHARMACEUTICALS, INC. 发明人 SUN YING;LIU DONG;OR YAT SUN;WANG ZHE
分类号 A61K38/00;A61K31/33;A61K38/12;C07D245/00;C07D513/00;C07K5/08 主分类号 A61K38/00
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