发明名称 |
Factor VIIa-Polysialic Acid Conjugate Having Prolonged In Vivo Half-Life |
摘要 |
The present invention relates to a proteinaceous construct comprising plasmatic or recombinant factor VIIa (FVIIa) or biologically active derivatives thereof, which are bound to a carbohydrate moiety comprising 1-4 sialic acid units, wherein the in vivo half-life of the proteinaceous construct is substantially prolonged in the blood of a mammal, as compared to the in vivo half-life of a FVIIa molecule not bound to a carbohydrate moiety. The invention also provides a method for controlling bleeding in a mammal having a bleeding disorder due to functional defects or deficiencies of FVIIa, FVIII, or FIX. The invention also provides a method for controlling bleeding in a mammal during surgery or trauma.
|
申请公布号 |
US2008221032(A1) |
申请公布日期 |
2008.09.11 |
申请号 |
US20070956634 |
申请日期 |
2007.12.14 |
申请人 |
BAXTER HEALTHCARE S.A.;BAXTER INTERNATIONAL INC. |
发明人 |
TURECEK PETER;SIEKMANN JUERGEN;SCHEIFLINGER FRIEDRICH;CANAVAGGIO MICHEL;CANAVAGGIO MARIE CHRISTINE |
分类号 |
A61K38/16;A61P7/02;C07K14/00 |
主分类号 |
A61K38/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|