PHARMACEUTICAL COMPOSITION CONTAINING PYRAZOLE DERIVATIVE

摘要

It is intended to provide a preparation, which contains a compound (I) having an improved elution property or a pharmaceutically acceptable salt thereof. It is also intended to provide a preparation, which contains a compound (I) having an improved elution property or a pharmaceutically acceptable salt thereof, and is stable. The invention enables the maintenance of the supersaturation state of a compound (I) or a pharmaceutically acceptable salt thereof and the improvement of absorption from the gastrointestinal tract by using a composition containing a solid dispersion of the compound (I) or pharmaceutically acceptable salt thereof and HPMC thereby suppressing the recrystallization of the solubilized compound (I) or pharmaceutically acceptable salt thereof in a solution. Further, by incorporating a substance, which can be coated on a tablet and dissolves or swells in water or a buffer in the acidic to neutral pH range, between the solid dispersion of the compound (I) or pharmaceutically acceptable salt thereof and HPMC, an effect of maintaining the supersaturation state can be imparted and a stable preparation can be provided.