发明名称 |
PROTEINS AND PROTEIN CONJUGATES WITH INCREASED HYDROPHOBICITY |
摘要 |
Examples may include a method of making a protein-PEG conjugate salt with increased hydrophobicity. The method may include providing an aqueous protein solution. This aqueous protein solution may include a protein and a pH buffer. The method may also include reacting a polyethylene glycol with the protein to form a protein-PEG conjugate. The method may further include protonating an amino group on the protein-PEG conjugate with a hydrophobic organic acid in an organic phase. The protonation may form the protein-PEG conjugate salt having a hydrophobic anion that increases the hydrophobicity-PEG conjugate salt. |
申请公布号 |
WO2016089818(A1) |
申请公布日期 |
2016.06.09 |
申请号 |
WO2015US63102 |
申请日期 |
2015.12.01 |
申请人 |
ANTRIABIO, INC. |
发明人 |
ROSENDAHL, MARY S.;MANTRIPRAGADA, SANKARAM B.;GOMEZ, ELIANA B. |
分类号 |
A61K9/50;A61K38/26 |
主分类号 |
A61K9/50 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|